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medicinal chemistry

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All discovered hit compounds are rigorously tested in several secondary assays in order to confirm their activity. In addition, we apply our synthetic chemistry expertise in extensive medicinal chemistry efforts to systematically modify the identified structures, often requiring the development of new synthetic approaches in order to facilitate the construction of analog collections. The goal is to obtain a detailed picture of the molecular requirements of each inhibitor for optimal function. In addition, we are converting those inhibitors into molecular probes by introducing functional handles for target identification.

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