medicinal chemistry
We are developing small molecules that target the microRNA pathway. MicroRNAs (miRNAs) are single-stranded noncoding RNAs of approximately 22 nucleotides that represent a new class of gene regulators. It is estimated that >30% of all genes and almost all genetic networks are, in part, controlled by miRNAs. Cancer, cardiovascular disease, and several viral infections have all been linked to the presence of specific miRNAs. Thus, developing small molecule modifiers for the miRNA pathway will have significant therapeutic implications. Click on the image on the right to learn more about the miRNA pathway.
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