synthetic chemistry
Almost all projects in the lab are based on the synthesis of organic molecules with new architecture and/or new biological function. We use these synthetic molecules to incorporate them into DNA and RNA followed by the optochemical control of oligonucleotide function. We develop small molecule inhibitors of the microRNA pathway as potential new therapeutic agents for the treatment of cancer and viral infection. We modify proteins with synthetic small molecules in order to enable optochemical control of these biological macromolecules in live cells and to provide them with new orthogonal chemistries.
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